Crossroads in carbon

Crossroads in Constraint Programming

Constraint programming is a declarative programming paradigm exploiting techniques stemming from research on combinatorial problems in computer vision, and robot planning. The paradigm comes close to the dream that users only need to simply state a problem and the computer will solve it, as underlined in the seminal 1996 article In Pursuit of the Holy Grail by Eugene Freuder. The idea is that p...

Evolutionary crossroads in developmental biology.

Common crossroads in diabetes management

The prevalence and impact of type 2 diabetes are reaching epidemic proportions in the United States. Data suggest that effective management can reduce the risk for both microvascular and macrovascular complications of diabetes. In treating patients with diabetes, physicians must be prepared not only to tailor the initial treatment to the individual and his or her disease severity but also to ad...

Editorial. At the crossroads.

Colposcopy at a crossroads.

New cervical cancer prevention strategies are arising from rapidly improving insight into human papillomavirus (HPV) natural history and cervical carcinogenesis, challenging the conventional roles of cytology and colposcopically directed biopsy as the reference standards of screening and diagnosis, respectively. HPV testing has high sensitivity but mediocre specificity and positive predictive v...